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Genistein promotes degradation of mutant androgen receptor
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Registered: 08-02-2009
Posts: 203
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Here's an old paper, but one that has not been commented on in this forum, as far as I know. A 2013 paper found that genistein promotes degradation of the mutant androgen receptor in a mouse model of KD. Genistein is a nutritional supplement derived from soybeans, and is commonly available at health food stores. Any thoughts? Here's a link to the original paper.
https://onlinelibrary.wiley.co...ll/10.1111/jnc.12172
Picture of ToddAllen
Location: Chicago, IL
Registered: 01-18-2008
Posts: 186
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I saw that paper but I never tried extracted genistein in supplement form. When possible I go for foods first and genistein is a phytoestrogen and I'm slightly concerned of the possibility it might aggravate gynecomastia increasing my hesitancy to start with a concentrated form. Having an intolerance for soy I saw that kudzu was also high in genistein and ordered powdered kudzu. But it tasted bad and gave me even more severe gut disruption than soy so I tossed the kudzu after 2 or 3 days. Genistein is only one of a rather long list of compounds potentially beneficial for KD and I've tried quite a few. But none of them have given me sufficiently immediate and profound results such that I am confident they are truly helping me. Perhaps some day when I have been in a long period of stability such that I could better detect subtle effects over a longer time frame I will try some of them again.

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