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EMG for KD
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Registered: 06-23-2020
Posts: 4
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Hello,

If you have KD and a neurologist performs as EMG test is there a particular pattern or signature concordant with KD please?
Picture of ToddAllen
Location: Chicago, IL
Registered: 01-18-2008
Posts: 205
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Yes, there are patterns to EMGs that are suggestive of KD. But the definitive test is the genetic test.
Registered: 08-02-2009
Posts: 204
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This article is rather technical but worth reading in answer to your question.

https://www.medscape.com/answe...f-kennedy-disease-kd
Registered: 06-23-2020
Posts: 4
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Thanks for the replies. Will the pattern be the same as ALS or different please?
Picture of ToddAllen
Location: Chicago, IL
Registered: 01-18-2008
Posts: 205
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There are roughly a couple dozen named varieties of ALS. Some named for the cause such as a genetic mutation and others named after a distinguishing pattern of expression. Some look sharply different from KD such as having predominantly upper motor neuron involvement. Others have more in common with bulbar and or lower motor neuron impacts more predominant. KD with a single genetic cause still has a fairly wide range of expression such that some have profound symptoms of androgen insensitivity making KD easier to diagnose while others don't.
Picture of ToddAllen
Location: Chicago, IL
Registered: 01-18-2008
Posts: 205
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Here's a new paper finding a serum myoglobin test may be a good way to diagnose between KD and ALS:

Myoglobin: A new biomarker for spinal and bulbar muscular atrophy?
https://sci-hub.tw/https://doi...0207454.2020.1796660
This study showed that the serum Myo levels increased in all patients with SBMA, but serum Myo levels in all patients with ALS were within the normal range.


It also looks like serum myoglobin may be useful for evaluating KD progression and response to therapies.
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